Wile E. Coyote and the Road Runner

Wile Ethelbert Coyote "Genius" and the Road Runner are the main duos from the Looney Tunes cartoons, Road Runner is the protagonist and Wile E. Coyote is the antagonist/anti-hero.

Overall

 * 1) The Road Runner and Wile E. Coyote have a great rivalry/chemistry with each other that it makes their rivalry one of the most memorable in cartoon history.
 * 2) * This is especially shown where they are essentially a parody of cat-vs.-mouse duos such as Tom and Jerry.
 * 3) Their designs are great.
 * 4) They both use signs to communicate with each other, which makes it funnier.
 * 5) The Road Runner is very optimistic and carefree while Wile E. Coyote is prideful and envious.
 * 6) They always follow Chuck Jones' rules for their cartoons correctly and don't screw up.
 * 7) A lot of their many Latin names on each cartoon are very funny.
 * 8) For nostalgic fans of them, Wile E. Coyote is better than Road Runner in hindsight when serving as this ultimately amusing, comically incompetent if pitiful bungler between the two.

Wile E. Coyote

 * 1) His comical defeats such as him falling off a cliff are very iconic.
 * 2) All of his expressions are very expressive and funny.
 * 3) The ways his traps for catching the Road Runner keep backfiring on him are very funny.
 * 4) Not only is he targeting the Road Runner, but he also wanted to capture Bugs Bunny.
 * 5) * Speaking of which, his new character depiction in New Looney Tunes had him form excellent chemistry as the comic foil to the more sly, self-aware Bugs, much to the point that it literally gave Daffy Duck a run for his money.
 * 6) His actual voice in the classic Bugs Bunny shorts is very charismatic.

The Road Runner

 * 1) The "Beep Beep" sounds that the Road Runner makes are very cute and iconic, as well as the cork-popping noise heard when he blows a raspberry.
 * 2) The Road Runner outsmarts Wile E. Coyote by beeping behind him where Wile would comically fail.
 * 3) The Road Runner is so fast that he can even give other speedy characters a run for their money.

Overall

 * 1) Their rivalry with each other started to become tiresome around the Larriva Eleven era, even the Road Runner was Flanderized around that time.
 * 2) They can break the rules to their cartoons from time to time.

Wile E. Coyote

 * 1) Much like Sylvester, Wile E Coyote can be a punching bag in a predictable fashion when he typically fails (this is especially evident where he was also often described as the epitome of the butt-monkey in Western Animation).
 * 2) * With that in mind; The constant running gag(s) of Wile's sheer ineptitude to catch the Road Runner, can get stale to the point of being predictable and boring.
 * 3) Where Wile was always arrogant, passionate, and self-deluded about being a "genius" when it comes to his rivalry with Bugs Bunny; he was always portrayed as inventive and smart yet extremely clumsy, clownish & gullible in the original shorts. His radical character depiction in New Looney Tunes with his higher levels of arrogance done in an intentionally unlikable way has made him become more snobbish, somewhat irrational and immature, and more of an imbecile than before.
 * 4) * Especially for how much he can be a hypocrite most of the time; while he treats Bugs like an absolute bumpkin he looks down upon on because of Wile's self-reliance and narcissism based on "higher intelligence", Wile continues to make a fool of himself because of Wile's shortcomings and Bug's stronger sense of rationality/common sense.
 * 5) While his actual voice in the classic shorts with him and Bugs Bunny is very charismatic and hammy, some viewers find it out to be unfitting or jarring.

The Road Runner

 * 1) He can be a little cruel to Wile E. Coyote at times, mainly during the Rudy Larriva era.
 * 2) Even though the Road Runner has a great design, he has a bad Sonic and Crash case of looking absolutely nothing like his real-life counterpart.

Videos
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